￭학력 및 경력 

2001 가천의과대 신경과 임상조교수

2002 가천의과대 신경과 조교수

2003-2006 의(신경과)학 박사, 한양대학교 의과대학 대학원 

2006 가천의과대 신경과 부교수

2008-2009 하버드의대 방문 및 연구 부교수

2011-현재 가천대 신경과 교수

2013-현재 가천뇌건강센터 뇌검진센터장

2014-현재 뇌과학연구원 연구기획조정실장, 뇌혈관질환연구센터장

2014-2016 미국뇌졸중학회(ASA) International Stoke Conference(ISC) Abstract Reviewer 

2017-2019 가천대 의과대학 교무부학장

2018-현재 가천대 의과대학 신경과 주임교수, 가천대 길병원 신경과 과장

￭소개 

초고자장강도의7T MRA를이용한뇌의미세혈관영상화를통한침습적인시술없이인간생체연구를가능하게하여, 뇌졸중(중풍) 초기단계연구와같은미세혈관이상에관한연구를수행하고있다. 특히임상적인측면에서기초연구팀과의긴밀한협업을통하여대뇌혈관질환의조기진단및치료에도움이될수있는포괄적개념의신경과학연구를수행하고있다. 또한, 자기공명영상(MRI), 단일광자방출컴퓨터단층촬영(SPECT), 양전자방출단층촬영(PET) 등의의료영상기기를활용한실험및영상획득기법개발연구를수행하고있으며, 의료영상분석기술을개발하고있다. 특히, 정상인과대뇌혈관질환환자의혈관의구조와기능의차이를규명하여대뇌혈관질환의기전을파악하여조기진단및위험도평가와더불어진단법개발을주된목표로삼고다양한수준에서의신경과학연구를수행하고있다.

￭키워드

뉴로이미징, 자기공명영상, 의료영상처리 

￭ 최근 연구업적(2018-현재)  (최근5년간의 주요연구실적)

1.   1. Hong JM, Lee JS, Lee YB, Shin DH, Shin DI, Hwang YH, Ahn SH, Kim JG, Sohn SI, Kwon SU, Lee JS, Gwag BJ, Ángel Chamorro, Dennis W. Choi Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial. Stroke. 2022 (IF=10.17 )

2.  2. Jung JY, Seo DK , Lee YB, Kang CK MRI-Compatible Microcirculation System Using Ultrasonic Pumps for Microvascular Imaging on 3T MRI. sensors. 2022 (IF=3.847)

3. Kang CK, Song MG, Yang JW, Lee HJ and Lee YB Severity Evaluation of Regional Cerebrovascular Reactivity in Acute Stroke Patients using SPECT. Current Medical Imaging. 2022 (IF=1.315 )

4.    4. Park HJ, Lee YB, Chang KA

miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3 gamma in early stage of 5xFAD mouse model of Alzheimer's disease. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. 2022 (IF=6.582 )

5.      Kim JH, Jung JY, Lee YB, Kang CK

Investigation of Flow Changes in Intracranial Vascular Disease Models Constructed with MRA Images. Sensors. 2022 (IF=3.576 )

6.      Jung JY, Lee YB, Kang CK

Novel Technique to Measure Pulse Wave Velocity in Brain Vessels Using a Fast Simultaneous Multi-Slice Excitation Magnetic Resonance Sequence. Sensors. 2021 (IF=3.576 )

7.      Lee YB, Kang CK

Cerebrovascular Reactivity Assessment during Carbon Dioxide Inhalation Using SPECT. APPLIED SCIENCES-BASEL. 2021 (IF=2.474 )

8.      Lee HJ, Lee EC, Seo SH , Ko KP , Kang JM , Kim WR , Seo HE , Lee SY, Lee YB, Park KH, Yeon BK, Nobuyuki Okamura, Na DL, Seong JK, Noh Y

Identification of Heterogeneous Subtypes of Mild Cognitive Impairment Using Cluster Analyses Based on PET Imaging of Tau and Astrogliosis. Frontiers in Aging Neuroscience. 2021 (IF=4.364 )

9.      Jung JY , Park CA , Lee YB, Kang CK

Investigation of Functional Connectivity Di erences between Voluntary Respirations via Mouth and Nose Using Resting State fMRI. Brain Sciences. 2020 (IF=3.332)

10.    Nam EJ, Lee YB, Cheil Moon, Chang KA

Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer’s Disease Progression. International Journal of Molecular Sciences. 2020 (IF=4.556 )

11.    Yoo SJ, Son GW, Bae JS , Kim SY, Yoo YK, Park DS, Baek SY, Chang KA, Suh YH, Lee YB, Hwang KS,  Kim YS,  Cheil Moon

Longitudinal profiling of oligomeric Aβ in human nasal discharge reflecting cognitive decline in probable Alzheimer’s disease. Scientific Reports. 2020 (IF=3.998 )

12.    Lee KJ, Park CA, Kang DH , Son YD, Kim HK, Lee YB, Kang CK

High-Resolution Imaging Using Keyhole-Based Compressed Sensing Averaging (CSAK) Technique. Journal of Magnetics. 2020 (IF=0.837)

13.    Lee KJ, Park CA, Lee YB, Kim HK, Kang CK

EEG signals during mouth breathing in a working memory task. INTERNATIONAL JOURNAL OF NEUROSCIENCE. 2020 (IF=1.852)

14.    Lee H, Seo SH, Lee SY, Jeong HJ, Woo SH, Lee KM, Lee YB, Park KH, Heo JH, Cindy W. Yoon, Kang JM, Jaelim Cho, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Na DL, Tatsuo Ido, Victor L. Villemagne,  and Noh Y

[18F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment. Journal of Clinical Neurology. 2020 Jan (IF=2.796 )

15.    Jeon S , Kang JM , Seo SH, Jeong HJ, Thomas Funck, Lee SY, Park KH, Lee YB, Yeon BK, Tatsuo Ido, Nobuyuki Okamura , Alan C. Evans, Na DL, Noh Y

Topographical Heterogeneity of Alzheimer’s Disease Based on MR Imaging, Tau PET, and Amyloid PET. Frontiers in Aging Neuroscience. 2019 (IF=4.362)

16.    Park CA, Yang SB, Lee KJ, Lee YB, Kim HK, Kang CK

Signal Changes in Hippocampal Subfields during Controlled Breathing Patterns by Using Functional MRI. Journal of the Korean Physical Society. 2019 (IF=0.630 )

17.    Jeon S, Kang JM, Seo S, Jeong HJ, Funck T, Lee SY, Park KH, Lee YB, Yeon BK, Ido T, Okamura N, Evans AC, Na DL, Noh Y. Comparison of the Effect of Fimasartan versus Valsartan on Blood Pressure Variability in Acute Ischemic Stroke: A Double-Blind Randomized Trial. Front. Aging Neurosci. 2019 (IF=3.633)

18.    Jeong HJ, Yoon CW, Seo S, Lee SY, Suh MK, Seo HE, Kim WR, Lee H, Heo JH, Lee YB, Park KH, Choi SH, Ido T, Lee KM, Noh Y. Relationships between [¹⁸F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia. J. Clin. Neurol. 2019 (IF=2.796)

19.    Lee H, Seo S, Lee SY, Jeong HJ, Woo SH, Lee KM, Lee YB, Park KH, Heo JH, Yoon CW, Kang JM, Cho J, Okamura N, Furumoto S, Yanai K, Na DL, Ido T, Villemagne VL, Noh Y. [18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia. Alzheimer Dis. Assoc. Dis. 2018 32, 1 (62-69) (IF=2.395)

20.    Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y. Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer’s disease. Neurobiol. Aging. 2018 59 (210-219) (IF=5.117)

21.    Yoo SJ, Cho B, Lee D, Son G, Lee YB, Soo Han H, Kim E, Moon C, Moon C. The erythropoietin-derived peptide MK-X and erythropoietin have neuroprotective effects against ischemic brain damage. Cell Death Dis. 2017 8, 8 (e3003) (IF=5.965)

22.    Mijajlović MD, Pavlović A, Brainin M, Heiss WD, Quinn TJ, Ihle-Hansen HB, Hermann DM, Assayag EB, Richard E, Thiel A, Kliper E, Shin YI, Kim YH, Choi S, Jung S, Lee YB, Sinanović O, Levine DA, Schlesinger I, Mead G, Milošević V, Leys D, Hagberg G, Ursin MH, Teuschl Y, Prokopenko S, Mozheyko E, Bezdenezhnykh A, Matz K, Aleksić V, Muresanu D, Korczyn AD, Bornstein NM. Post-stroke dementia – a comprehensive review. BMC Med. 2017 15, 1 (11) (IF=8.097)

* 홈페이지

(개인 홈페이지) http://blog.naver.com/nryblee

(뇌혈관질환 연구센터) http://nri.gachon.ac.kr/c_2014_06_e.html