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융합의과학과

교수소개

의생명과학 전공 참여교수 및 프로필입니다.

장근아, Ph.D.
소속 및 직위
소속: 의과대학 의예과   직위: 교수
실험실명
뉴로랩 (NEURO LAB)
연구분야
신경약리
연구실위치
가천대학교 이길여암·당뇨연구원 N404
전공분야
신경약리학, 뇌신경과학, 퇴행성 뇌질환
  • +82-32-899-6411
  • keuna705@gachon.ac.kr
  • +82-32-820-4744
  •  학력 및 경력 

     

    2004 의학박사 (약리학), 서울대학교

    2012-현재 조교수, 부교수, 가천대학교

    2014-2020 뇌과학연구원 나노유전체센터 센터장

    2021-현재 뇌과학연구원 기초연구부 부장/정서인지연구센터 센터장

     


     소개

     

    뉴로랩 연구실에서는 알츠하이머 치매를 포함한 퇴행성 뇌질환의 기전 및 치료법 개발을 주된 목표로 삼고 다양한 수준에서의 연구를 수행하고 있다또한 인지신경행동에 관한 연구도 활발하게 진행하고 있다.  

     

     

     키워드

     

    퇴행성 뇌질환, 학습-기억, 우울증 

     

     

     최근 연구업적(2022-현재)

    1.      Bo Hyun Yoon, Jinho Kim, Sandip Sengupta, Chan-Jung Park, Minjoo Ko, Ji Hee Kang, Young Tag Ko, Yeji Kim,Seung Min Lim, Yoonhee Bae, MooYoung Choi, Yunyeong Jang, Ho Jeong Kwon, Hyo Jin Son, Hee Jin Kim, Taebo Sim*,Keun-A Chang* and Myung-Shik Lee*(2025) Targeted autophagic clearance of Tau protects against Alzheimer’s disease through amelioration of Tau-mediated lysosomal stress. Theranostics. 2025; 15(17): 9240-9260 (*Co-corresponding authors)

    2.      Kim Y, Ha TY, Lee MS*, Chang KA* (2025)Regulatory Mechanisms and Therapeutic Implications of Lysosomal Dysfunction in Alzheimer's Disease.Int J Biol Sci. 21(3):1014-1031.

    3.      Ko G, Kim J, Hong Y, Jeon YJ, Baek HM, Lee D, Chang KA (2025) Astragalus mongholicus and Scutellaria baicalensis Extracts Mixture Target Pyroptosis in Ischemic Stroke via the NLRP3 Pathway.Int J Mol Sci. 26(2):501.

    4.      Hong Y, Ko G, Jeon YJ, Baek HM, Lee J, Lee D, Park J, Kim J, Chang KA (2025)Neuroprotective Efficacy of Astragalus mongholicus in Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms.Cells. 14(2):117

    5.      Md Samsuzzaman, Hong SM, Lee JH, Park H, Chang KA, Kim HB, Park MG, Eo H, Oh MS, Kim SY. (2024) Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration.Biol Res. 57(1):87.

    6.      Jung SC, Jang W, Beom B, Won JK, Jeong J, Choi YJ, Moon MK, Cho ES, Chang KA, Han JH. (2024) Synthesis of Highly Porous Graphene Oxide-PEI Foams for Enhanced Sound Absorption in High-Frequency Regime.Polymers (Basel). 16(21):2983

    7.      Ha TY, Kim JB, Kim Y, Park SM, Chang KA (2024)GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson's disease animal models.Pharmacol Res. 209:107432

    8.      Kim KY, Shin KY, Chang KA (2024)Potential Exosome Biomarkers for Parkinson's Disease Diagnosis: A Systematic Review and Meta-Analysis. Int J Mol Sci. 25(10):5307

    9.      Sharma H, Chang KA, Hulme J, An SSA. (2023) Mammalian Models in Alzheimer's Research: An Update.Cells.12(20):2459

    10.   Kim KY, Shin KY, Chang KA (2023) Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review. Int J Mol Sci. 24(18):13907.

    11.   Seo HW, Ha TY, Ko G, Jang A, Choi JW, Lee DH, Chang KA (2023)Scutellaria baicalensis Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice, Cells, 12(17):2133.

    12.   Kim Y, Kim J, Kang S, Chang KA (2023) Depressive-like Behaviors Induced by mGluR5 Reduction in 6xTg in Mouse Model of Alzheimer's Disease, Int J Mol Sci. 24(16):13010.

    13.   Kim KY, Shin KY, Chang KA (2023)GFAP as a Potential Biomarker for Alzheimer's Disease: A Systematic Review and Meta-Analysis, Cells12(9):1309.

    14.   Ko, G.; Kim, J.; Jeon, Y.-J.; Lee, D.; Baek, H.-M.; Chang, K.-A (2023) Salvia miltiorrhiza Alleviates Memory Deficit Induced by Ischemic Brain Injury in a Transient MCAO Mouse Model by Inhibiting Ferroptosis. Antioxidants 12, 785.

    15.   Yoo, C.-H.; Kim, J.; Baek, H.-M.*; Chang, K.-A*; Choe, B.-Y. (2023) Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer’s Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy. Int. J. Mol. Sci. 5073. (*Co-corresponding authors)

    16.   Jeon YJ, Park SE, Chang KA, Baek HM (2022) Signal-to-Noise Ratio Enhancement of Single-Voxel In Vivo 31P and 1H Magnetic Resonance Spectroscopy in Mice Brain Data Using Low-Rank Denoising. Metabolites. 12(12):1191.

    17.   Kim J, Kang S, Chang KA (2022) Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model. Int J Mol Sci. 23(18):10602

    18.   Jung DH, Son G, Kwon OH, Chang KA, Moon C (2022) Non-Invasive Nasal Discharge Fluid and Other Body Fluid Biomarkers in Alzheimer's Disease. Pharmaceutics.14(8):1532

    19.   Kang S, Kim J, Lee SY, Okamura N, Chang KA (2022) MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6×Tg Alzheimer's Disease Model Mice. Int J Mol Sci. 23(10):5485

    20.   Park H, Lee YB, Chang KA (2022) miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease. Int J Biol Sci.18(5):2220-2234

    21.   Kim J, Kang S, Choi TY, Chang KA*, Koo JW* (2022) Metabotropic glutamate receptor 5 in amygdala target neurons regulates susceptibility to chronic social stress. Biological Psychiatry, 92(2):104-115 (*Co-corresponding authors)

    22.   Tag SH, Kim B, Bae J, Chang KA, Im HI(2022) Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease. Mol Brain.15(1):51

    23.   Kim KY, Shin KY, Chang KA (2022) Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis. Int J Mol Sci. 23(2):602. 

    24.   An SSA, Shim KH, Kang S, Kim YK, Subedi L, Cho H, Hong SM, Tan MA, Jeon R*Chang KA*, Kim SY* (2022) The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease.Br J Pharmacol. 179(5):1033-1048 (*Co-corresponding authors)