융합의과학과
교수소개
의생명과학 전공 참여교수 및 프로필입니다.
- 소속 및 직위
- 소속: 의과대학 의예과 직위: 교수
- 실험실명
- 뉴로랩 (NEURO LAB)
- 연구분야
- 신경약리
- 연구실위치
- 가천대학교 이길여암·당뇨연구원 N404
- 전공분야
- 신경약리학, 뇌신경과학, 퇴행성 뇌질환
- +82-32-899-6411
- keuna705@gachon.ac.kr
- +82-32-820-4744
￭ 학력 및 경력
2004 의학박사 (약리학), 서울대학교
2012-현재 조교수, 부교수, 가천대학교
2014-2020 뇌과학연구원 나노유전체센터 센터장
2021-현재 뇌과학연구원 기초연구부 부장/정서인지연구센터 센터장
￭ 소개
뉴로랩 연구실에서는 알츠하이머 치매를 포함한 퇴행성 뇌질환 치료법의 개 발을 주된 목표로 삼고 다양한 수준에서의 연구를 수행하고 있다. 또한 인지 신경행동에 관한 연구도 활발하게 진행하여, 인지와 행동을 조절하는 신경회 로망에 대해서도 연구하고 있다
￭ 키워드
퇴행성 뇌질환, 학습-기억, 우울증
￭ 최근 연구업적(2021-현재)
1:Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model. Int J Mol Sci. 2022 Sep 13;23(18):10602 (교신)
2: Non-Invasive Nasal Discharge Fluid and Other Body Fluid Biomarkers in Alzheimer's Disease. Pharmaceutics. 2022 Jul 22;14(8):1532 (공동)
3: MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6×Tg Alzheimer's Disease Model Mice. Int J Mol Sci. 2022 May 14;23(10):5485 (교신)
4: miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease. Int J Biol Sci. 2022 18(5):2220-2234 (교신)
5: Metabotropic glutamate receptor 5 in amygdala target neurons regulates susceptibility to chronic social stress. Biological Psychiatry, 2022 Jul 15;92(2):104-115(교신)
6: Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease. Mol Brain. 15(1):51 (공동)
7: Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis. Int J Mol Sci. 2022 Jan 6;23(2):602 (교신)
8: In Vivo Cerebral Translocator Protein (TSPO) Binding and Its Relationship with Blood Adiponectin Levels in Treatment-Naïve Young Adults with Major Depression: A[11C]PK11195 PET Study. Biomedicines.10(1):34 (공동)
9: The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease. Br J Pharmacol. 2022 Mar;179(5):1033-1048(교신)
10: Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice. Antioxidants (Basel). 2021 Aug 23;10(8):1321 (교신)
11: Brain-Derived Exosomal Proteins as Effective Biomarkers for Alzheimer's Disease: A Systematic Review and Meta-Analysis. Biomolecules. 2021 Jul 3;11(7):980. (교신)
12: Sex Difference in Peripheral Inflammatory Biomarkers in Drug-Naïve Patients with Major Depression in Young Adulthood. Biomedicines. 2021 Jun 22;9(7):708. (교신)
13: Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model. Sci Rep. 2021 Jan 14;11(1):1334. (교신)
14: Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice. Mol Brain. 2021 Jan 13;14(1):11. (교신)
15: Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson's Disease. Int J Mol Sci. 2021 Jan 11;22(2):654. (교신)
16: Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice. Alzheimers Res Ther. 2021 Jan 4;13(1):4. (공동)
17: RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease. Neuropathol Appl Neurobiol. 2021 Aug;47(5):625-639 (공동)
