융합의과학과
의생명과학 전공 참여교수 및 프로필입니다.
■ 학력 및 경력
2004 의학박사 (약리학), 서울대학교
2012-현재 조교수, 부교수, 가천대학교
2014-2020 뇌과학연구원 나노유전체센터
센터장
2021-현재 뇌과학연구원 기초연구부 부장/정서인지연구센터 센터장
■ 소개
뉴로랩 연구실에서는 알츠하이머 치매를 포함한 퇴행성 뇌질환의 기전 및 치료법 개발을 주된 목표로 삼고 다양한 수준에서의 연구를 수행하고 있다. 또한 인지신경행동에 관한 연구도 활발하게 진행하고 있다.
■ 키워드
퇴행성 뇌질환, 학습-기억, 우울증
■ 최근 연구업적(2022-현재)
1. Bo
Hyun Yoon, Jinho Kim,
Sandip Sengupta, Chan-Jung Park, Minjoo Ko, Ji Hee Kang, Young Tag Ko, Yeji Kim,Seung Min Lim, Yoonhee Bae, MooYoung Choi, Yunyeong
Jang, Ho Jeong Kwon, Hyo Jin Son, Hee Jin Kim, Taebo Sim*,Keun-A Chang* and Myung-Shik Lee*(2025)
Targeted autophagic clearance of Tau protects against Alzheimer’s disease
through amelioration of Tau-mediated lysosomal stress. Theranostics. 2025; 15(17): 9240-9260 (*Co-corresponding
authors)
2.
Kim Y, Ha TY, Lee MS*, Chang
KA* (2025)Regulatory
Mechanisms and Therapeutic Implications of Lysosomal Dysfunction in Alzheimer's
Disease.Int J Biol Sci. 21(3):1014-1031.
3.
Ko G, Kim J, Hong Y, Jeon YJ,
Baek HM, Lee D, Chang KA (2025)
Astragalus mongholicus and Scutellaria baicalensis Extracts
Mixture Target Pyroptosis in Ischemic Stroke via the NLRP3 Pathway.Int J Mol Sci. 26(2):501.
4.
Hong Y, Ko G, Jeon YJ, Baek
HM, Lee J, Lee D, Park J, Kim J, Chang KA (2025)Neuroprotective Efficacy of Astragalus mongholicus in
Ischemic Stroke: Antioxidant and Anti-Inflammatory Mechanisms.Cells. 14(2):117
5.
Md
Samsuzzaman, Hong SM, Lee JH, Park H, Chang KA, Kim HB, Park MG, Eo
H, Oh MS, Kim SY. (2024) Depression like-behavior
and memory loss induced by methylglyoxal is associated with tryptophan depletion
and oxidative stress: a new in vivo model of neurodegeneration.Biol Res. 57(1):87.
6.
Jung SC,
Jang W, Beom B, Won JK, Jeong J, Choi YJ, Moon MK, Cho ES, Chang KA,
Han JH. (2024) Synthesis of Highly Porous Graphene Oxide-PEI
Foams for Enhanced Sound Absorption in High-Frequency Regime.Polymers (Basel). 16(21):2983
7.
Ha TY, Kim
JB, Kim Y, Park SM, Chang KA (2024)GPR40 agonist ameliorates
neurodegeneration and motor impairment by regulating NLRP3 inflammasome in
Parkinson's disease animal models.Pharmacol
Res. 209:107432
8. Kim KY, Shin KY, Chang KA (2024)Potential Exosome
Biomarkers for Parkinson's Disease Diagnosis: A Systematic Review and
Meta-Analysis. Int J Mol Sci. 25(10):5307
9. Sharma H, Chang KA, Hulme J, An SSA. (2023) Mammalian Models
in Alzheimer's Research: An Update.Cells.12(20):2459
10. Kim KY, Shin KY, Chang KA (2023) Potential Inflammatory Biomarkers for Major Depressive
Disorder Related to Suicidal Behaviors: A Systematic Review. Int J
Mol Sci. 24(18):13907.
11. Seo HW, Ha TY, Ko G, Jang A, Choi JW, Lee DH, Chang KA (2023)Scutellaria
baicalensis Attenuated Neurological Impairment by Regulating Programmed
Cell Death Pathway in Ischemic Stroke Mice, Cells, 12(17):2133.
12. Kim Y, Kim J, Kang S, Chang KA (2023) Depressive-like Behaviors Induced by mGluR5 Reduction in 6xTg in
Mouse Model of Alzheimer's Disease, Int J Mol Sci. 24(16):13010.
13. Kim KY, Shin KY, Chang KA (2023)GFAP as a Potential Biomarker for
Alzheimer's Disease: A Systematic Review and Meta-Analysis, Cells12(9):1309.
14. Ko, G.; Kim, J.; Jeon, Y.-J.; Lee, D.; Baek, H.-M.; Chang, K.-A (2023) Salvia
miltiorrhiza Alleviates Memory Deficit Induced by Ischemic Brain
Injury in a Transient MCAO Mouse Model by Inhibiting Ferroptosis. Antioxidants 12, 785.
15. Yoo, C.-H.; Kim, J.; Baek, H.-M.*; Chang,
K.-A*; Choe, B.-Y. (2023) Neurodegenerative Changes in the Brains of the
5xFAD Alzheimer’s Disease Model Mice Investigated by High-Field and
High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance
Spectroscopy. Int. J. Mol. Sci. 5073. (*Co-corresponding
authors)
16. Jeon YJ, Park SE, Chang KA, Baek HM (2022) Signal-to-Noise
Ratio Enhancement of Single-Voxel In Vivo 31P and 1H
Magnetic Resonance Spectroscopy in Mice Brain Data Using Low-Rank Denoising. Metabolites. 12(12):1191.
17. Kim J, Kang S, Chang KA (2022) Effect of cx-DHED on Abnormal Glucose Transporter Expression
Induced by AD Pathologies in the 5xFAD Mouse Model. Int J Mol Sci. 23(18):10602
18. Jung DH, Son G, Kwon OH, Chang KA, Moon C (2022) Non-Invasive Nasal Discharge Fluid and Other Body Fluid Biomarkers in
Alzheimer's Disease. Pharmaceutics.14(8):1532
19. Kang S, Kim J, Lee SY, Okamura N, Chang KA (2022) MicroPET
Imaging Assessment of Brain Tau and Amyloid Deposition in 6×Tg Alzheimer's
Disease Model Mice. Int J Mol Sci. 23(10):5485
20. Park H, Lee YB, Chang KA (2022) miR-200c suppression increases tau hyperphosphorylation by
targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease. Int J
Biol Sci.18(5):2220-2234
21. Kim J, Kang S, Choi TY, Chang KA*, Koo JW* (2022)
Metabotropic glutamate receptor 5 in amygdala target neurons regulates
susceptibility to chronic social stress. Biological Psychiatry, 92(2):104-115 (*Co-corresponding authors)
22. Tag SH, Kim B, Bae J, Chang KA, Im HI(2022) Neuropathological and behavioral features of an APP/PS1/MAPT
(6xTg) transgenic model of Alzheimer's disease. Mol Brain.15(1):51
23.
Kim KY, Shin KY, Chang
KA (2022) Potential
Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and
Meta-Analysis. Int J Mol Sci. 23(2):602.
24. An SSA, Shim KH, Kang S, Kim YK, Subedi L, Cho H, Hong SM, Tan MA, Jeon
R*, Chang KA*, Kim SY* (2022) The potential anti-amyloidogenic
candidate, SPA1413, for Alzheimer's disease.Br
J Pharmacol. 179(5):1033-1048 (*Co-corresponding
authors)