￭ 학력 및 경력 

2005 이학박사, 경상대학교 생화학과

2005-2008 박사 후 연구원, 경상대학교 응용생명과학부

2008-현재 교수, 가천대학교 의과대학 의예과 생화학 교실

￭ 소개

본 연구실은 크게 1) 레독스-조절 단백질 중심으로 질병연관인자의 선택적 단백질 분해 기전을 이해하기 위해 세포주, 동물모델, 임상조직에 기반한 연구, 2) 단백질 의약품을 개선을 위한 시스템 개발 연구에 중점을 두고 연구하고 있다.

￭ 키워드

활성산소, 레독스-조절단백질, 선택적 단백질 분해, 단백질 의약품 

￭ 최근 연구업적(2018-현재)  (최근 5년간의 주요연구실적)

1. Prx1 Regulates Thapsigargin-Mediated UPR Activation and Apoptosis, Genes (2022) 13: 2033

2. SILAC-Based Quantitative Proteomic Analysis of Oxaliplatin-Resistant Pancreatic Cancer Cells, Cancers (2021) 13:724.

3. Clinicopathologic Analysis of Cathepsin B as a Prognostic Marker of Thyroid Cancer. International Journal of Molecular Sciences (2020) 21: 9537.

4. Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis. Cancer Genomics & Proteomics (2019) 16: 583-592.

5. Redox-Mediated Mechanism of Chemoresistance in Cancer Cells. Antioxidants (2019) 8: 471.

6. Mts1 Up-regulation is Associated With Aggressive Pathological Features in Thyroid Cancer. Cancer Genomics & Proteomics (2019) 16: 369-376.

7. Peroxiredoxin 1 post-transcriptionally regulates snoRNA expression. Free. Radic. Biol. Med. (2019) 141: 1-9.

8. Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling. Antioxidants (2019) 8: 169.

9. Prx2 links ROS homeostasis to stemness of cancer stem cells. Free. Radic. Biol. Med. (2019) 134:260-267.